Evaluation of Cytotoxic Activities of Disinfectants on Human Healthy Cells

Abstract

The Covid-19 pandemic, including our country, has affected 34 million people around the world and caused high death rates and still is. One of the most important points in this process is disinfection, and both surface and air disinfectants have been used frequently. Disinfectants, which are extremely diversified in the market, have started to create danger while protecting us from the virus. It is known that the disinfectants used prevent the contagion of the virus, but we do not have clear information about whether they have destructive effects on the healthy cells of the people who use them. Therefore, in our study, it was aimed to determine the effects of hand disinfectants produced by various brands on our healthy cells. In our study, first of all, the most widely used disinfectants were obtained from the market, and then the cytotoxic (lethal) activity of these disinfectants on healthy cells was determined by in vitro MTT ((3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) analysis. As a result of this study, it was observed that apart from the disinfectant containing hypochlorous acid, other disinfectants have cytotoxic activity against healthy human cells. Despite the increasing need during the pandemic process, we recommend that these disinfectant substances, which are put on the market in large numbers and in a wide variety, should be inspected and necessary measures should be taken so that they can be sold after passing through the quality control stages.