Abstract
One of the challenges of radiation oncology in the era of personalized medicine is identification of biomarkers associated with individual radiosensitivity. The aim of research was to evaluate the possible clinical value of the associations between clinical, physical, and biological factors, and risk for development of acute radiotoxicity in patients with prostate cancer. The study involved forty four patients treated with three-dimensional conformal radiotherapy. The concentrations of IL-1β, IL-2, IL-6, IFN-γ and TGF-β1 were assessed before radiotherapy, after 5th, 15th and 25th radiotherapy fractions, at the end, and 1 month after the end of radiotherapy. Cytokine gene expression was determined in peripheral blood mononuclear cells. The univariate analysis of circulating cytokine levels during radiotherapy showed that increased serum concentrations of IL-6 were significantly associated with higher grade of acute genitourinary toxicity. The multivariate analysis demonstrated that increased level of IL-6 during the radiotherapy was significantly associated with higher grade of acute genitourinary toxicity across treatment. TGF-β expression levels significantly decreased during course of radiotherapy. Research indicates that changes in circulating cytokine levels might be important parameter of radiotoxicity in patients with prostate cancer. These findings suggest that future studies based on multi-parameter examination are necessary for prediction of individual radiosensitivity.
Highlights
One of the challenges of radiation oncology in the era of personalized medicine is identification of biomarkers associated with individual radiosensitivity
Christensen et al.[5] found that circulating IL-6 was significantly elevated in patients with prostate cancer during radiotherapy, this increase of IL-6 level was not associated with acute genitourinary toxicity as it was observed in our study
Our study shows that changes in circulating cytokine levels during the course of radiation therapy rather than absolute levels might be important parameters of radiotoxicity
Summary
One of the challenges of radiation oncology in the era of personalized medicine is identification of biomarkers associated with individual radiosensitivity. The univariate analysis of circulating cytokine levels during radiotherapy showed that increased serum concentrations of IL-6 were significantly associated with higher grade of acute genitourinary toxicity. Research indicates that changes in circulating cytokine levels might be important parameter of radiotoxicity in patients with prostate cancer. These findings suggest that future studies based on multi-parameter examination are necessary for prediction of individual radiosensitivity. Cytokine expression is associated with radiation-related tissue damage and inflammation, and may serve as an indicator of cell and tissue toxicity during prostate cancer r adiotherapy[5,6]. Changes in levels of proinflammatory cytokines have been associated with radiation-induced toxicity, and with tumor response to radiotherapy. The aim of the present study was to examine the potential clinical significance of the associations between clinical, physical, and multiple biological parameters from three different levels, which derived from the previous study which investigated association only between clinico-pathological and physical parameters and potential risk for development of acute r adiotoxicity[17]
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