Abstract
Tebuconazole-based fungicide (group of triazole fungicides, with 25% of active agent) was evaluated for their ability to induce sister chromatid exchange (SCE) and proliferation indices (PI) in cultured bovine peripheral lymphocytes. The cultures were treated with the fungicides at the concentrations ranged from 3 to 60 µg.ml -1 for the last 24 and 48 h of incubation. Positive results in the SCE induction were obtained after the exposure to tebuconazole for the last 24h of incubation. The highest concentration of the fungicide also reflected in reduction of proliferation activity, but only insufficient number of cells could be analysed. Our results correspond to our previous finding from the CA assay (chromosomal aberrations) in bovine peripheral lymphocytes treated with the fungicide. Prolonged time of exposure provided inadequate evidence for the genotoxic activity of the fungicide.
Highlights
Conazoles are a large family of synthetic fungicides used extensively in agricultural applications
The results obtained from the sister chromatid exchange (SCE) studies and the lymphocyte proliferation kinetics are summarised in Tables 1 and 2
The tebuconazole-based fungicide tested in bovine peripheral lymphocytes was shown to be able to induce cellular lesions that lead to SCE formation and/or to the death of cells
Summary
Conazoles are a large family of synthetic fungicides used extensively in agricultural applications. Conazole fungicides containing triazoles as active ingredients (e.g., myclobutanil, propiconazole, and triadimefon) are the most effective agents on fruit, vegetables, cereals, and seeds protection against. On the basis of the results of experimental studies efficacies of triazole fungicides ranged from 25% to 89% (Haidukowski et al.2005) and depended on the time of application. Several conazole compounds were used pharmaceutically, primarily for the treatment of candidiasis, cryptococcosis, and coccidiomycosis (Rockett et al 2006). Tebuconazole is efficient against broad spectra of fungous diseases. It belongs to the most widely used triazole fungicide in the European Union
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