Abstract
AbstractIonic liquids have drawn increasing attention in separation science recently. As a new promising brand of surfactants, ionic‐liquid‐based surfactants have their unique properties and superior aggregation behavior, which can be introduced as micelle‐forming surfactants in micellar electrokinetic capillary chromatography mode. There have been few reports of the applications of ionic‐liquid‐based surfactants for micellar electrokinetic capillary chromatography enantioseparation. In this study, pyrrolidinium‐based ionic liquids surfactants were applied for the first time for chiral separation with hydroxypropyl‐β‐cyclodextrin as a chiral selector by micellar electrokinetic capillary chromatography. As observed, the established micellar electrokinetic capillary chromatography systems with ionic‐liquid‐based surfactants could provide better separation of tested chiral drugs than conventional non‐ionic liquid cationic surfactant. In addition, parameters such as the alkyl chain length, concentration of ionic‐liquid‐based surfactants, type and proportion of organic modifier, concentration of chiral selector and composition and pH of buffer solution were systematically investigated to optimize the cyclodextrin‐micellar electrokinetic capillary chromatography system.
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