Abstract
Abstract Overexposure of human skin to solar ultraviolet radiation (UVR) is known to produce deleterious effects including cutaneous photoaging and cancers. The present studies were conducted to confirm the utility of a commercially available full-thickness reconstructed human skin model (EpiDermFT) for reproducing tissue and cellular effects involved in cutaneous responses to acute solar UVR exposure. EpiDermFT tissues were irradiated with a single acute UVR dose approximately equivalent to either 6 or 9.5 minimal erythemal doses. Cutaneous damage and recovery were then monitored for a period of 7 days. Excised human skin specimens were treated under identical conditions for comparison. The UVR exposures resulted in pronounced structural and morphological alterations in both the EpiDermFT and excised skin tissues. Both models demonstrated a similar timecourse of sunburn cell (SBC) formation, epidermal necrosis, acantholysis and parakeratosis, and regeneration. The EpiDermFT model also reproduced key aspe...
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