Evaluation of CT perfusion parameters for assessment of split renal function in healthy donors

Abstract

ObjectivesTo assess feasibility of automatically calculated CT perfusion parameters using two different methods of drawing regions of interest (ROIs) to reflect split renal function in comparison with MAG3 renography. Methods and materials51 potential kidney donors (24 males, 27 females) were prospectively evaluated by preoperative CT perfusion. Post processing was done twice; one with ROI around renal cortex only and the other around cortex and medulla. Perfusion parameters (perfusion, peak enhancement intensity PEI and blood volume BV) were compared between the two methods. Split values for each of these parameters were calculated and compared to split renal function measured by MAG3 renography using paired samples t test. ResultsPerfusion was significantly lower in method 2 than in method 1 while PEI and BV showed no significant difference between the two methods. Split values of CT parameters showed no significant difference from corresponding renography split function (p value>0.1) except BV by method 1 and perfusion by method 2 which showed significant difference (p value<0.05). ConclusionCertain CT perfusion parameters can reflect split renal function. Perfusion was more accurate in reflecting split renal function with ROI around the cortex while BV was more accurate with ROI around the whole parenchyma.