Abstract
Patients with asthma have an ongoing inflammation, which can be assessed by measuring serum C- reactive protein. Objective: To explore whether CRP could be used as a predictor of disease outcome in asthma. Methods: A Cross-sectional study was conducted among 50 asthma patients attending Respiratory Medicine outpatient services in Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016. Patients aged 18-67 were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. Computerized Spirometer Helios 401 was the instrument used to measure lung volumes and capacities. BeneSpheraTM CRP Latex Slide test kit was used to estimate serum C-reactive protein. Results and Observation: The present study was conducted on fifty asthma patients in which serum CRP level showed association with severity of asthma ( p=0.001) but serum CRP level with spirometric parameters showed significant negative correlation; FVC (r=-0.711, p<0.001), FEV1 (r=-0.665, p<0.001), FEV1/FVC (r=-0.429, p=0.002), FEF25-75% (r=-0.535, p<0.001), and PEFR (r=-0.515, p<0.001). Conclusion: In our study we found association between serum CRP level and asthma and plasma CRP may be used as a marker of prognosis in patients with asthma.
Highlights
Asthma is one of the most common chronic disease and currently affects nearly 300 million people globally
In our study we found association between serum CRP level and asthma and plasma CRP may be used as a marker of prognosis in patients with asthma
Study design A Cross-sectional study was conducted among 50 asthma patients attending Respiratory Medicine outpatient services in Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016
Summary
Asthma is one of the most common chronic disease and currently affects nearly 300 million people globally. The prevalence of asthma has risen in affluent countries over the past 30 years with 10-12% of adults and 15% of children affected by the disease.[1]. 2 The chronic inflammation of the airway causes recurrent episodes of wheezing, chest tightness, breathlessness, and coughing, at night and in the early morning. These episodes are usually associated with wide spread but variable airflow obstruction that is often reversible either spontaneously or with treatment.[2]. Spirometry assesses the obstruction of expiratory airflow, which is the characteristic functional defect. Spirometry is the most effective way of determining the severity of obstructive airway diseases.[3]
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