Abstract
The preparation of cross-linked cassava starch microspheres (CCSM) using catalyst sodium chloride and cross-linker sodium trimetaphosphate as drug delivery matrices has been studied. The CCSM's functional groups, freeze-thaw stability, swelling power, solubility, and gelatinization capabilities have been evaluated. The morphological structure, drug loading, and particle size of the AA encapsulation were also investigated. The water solubility and swelling degree increased after the modification via cross-linking, and then the morphology exhibited bell-shaped granules and a smooth, rounded surface. The drug delivery was analyzed using three dissolution mediums: 0.1 M of HCl, buffered saline phosphate (PBS pH of 7.4), and NaCl solution (9%). The PBS solvent resulted in a much better performance in drug delivery. The loading capacity, encapsulation efficiency, and release rate after 150 min of the AA were 31.490.20%, 89.840.23%, and 81.580.10%, respectively.
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