Abstract
Diopsys®NOVA™ is a novel full-field electroretinography (ffERG) device that can make rapid measurements of retinal electrophysiologic function. Diagnosys® Espion 2™ is a clinical gold-standard ERG device. This study aimed to investigate whether light-adapted Diopsys®NOVA™ fixed-luminance flicker ffERGmagnitude andimplicit time (converted from phase) measurements correlate with light-adapted Diagnosys®Espion 2™ flicker ffERG amplitude and implicit time measurements, respectively. Twelve patients (22 eyes) with various retinal and uveitic diseases underwent light-adapted Diagnosys®Espion 2™ and Diopsys®NOVA™ fixed-luminance flicker testing. Diopsys®magnitude and implicit time (converted from phase)measurements were compared to Diagnosys®amplitude and implicit timemeasurements, and a Pearson correlation was used to evaluate any existing correlation. Groups were also compared using generalized estimating equations. Bland-Altman plots were utilized to determine agreement between the comparison groups. Age of patients ranged from 14 to 87 years. 58% (n = 7/12) of patients were female. A significant, positive correlation (r = 0.880, P < 0.001) was observed betweenmagnitude(Diopsys®) andamplitude(Diagnosys®) measurements. Amplitude increases by 6.69µV for each 1µV increase in Magnitude (p-value < 0.001). A statistically significant, strong positive correlation was observed between Diopsys® implicit time measurements (converted from phase) and Diagnosys® implicit time measurements (r = 0.814, p-value < 0.001). For each 1ms increase in Diopsys® implicit time, Diagnosys® implicit time increases by 1.13ms (p-value < 0.001). There is a statistically significant positive correlation between light-adapted Diopsys®NOVA™ fixed-luminance flicker amplitudeand Diagnosys®flickermagnitude values. Additionally, there is a statistically significant positive correlation between Diopsys®NOVA™ fixed-luminance flicker implicit time (converted from phase) and Diagnosys®flickerimplicit time values. These results imply that the Diopsys®NOVA™ module, which utilizes the nonstandard shortened International Society for Clinical Electrophysiology of Vision (ISCEV) ERG protocol, can produce reliable light-adapted flicker ffERG measurements.
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