Evaluation of Congenital and Chromosomal Anomalies Mortality in Turkey by Joinpoint Regression Analysis

Abstract

Congenital anomalies (CAs) represents one of the main cause of fetal death, infant mortality and morbidity, and long-term disability. This study aims that it was to analyze the mortality trends of Congenital and Chromosomal Anomalies (CCAs) mortality in Turkey. This population-based observational study covers nine years in Turkey. CCAs mortality data was reported from the Turkish Statistical Institute death database by gender and age. Age-standardized mortality rates per 100,000 population were calculated by direct standardization using the WHO Reference Population. Average annual percent change (AAPC), annual percent change (APC), and 95% confidence interval (CI) were computed using the joinpoint regression analysis. Joinpoint Regression analysis results showed a significant trend for overall CCA-type mortality over the entire observation period (AAPC=3.9%, 95% CI:1.4 to 6.4). A significant increase in the mortality rate of nervous system (in male: APC:7.6%, 95% CI: 2.2 to 13.4; in female: APC:6.6%, 95% CI:2.6 to 10.7) and circulatory system (in male: APC:4.6%, 95% CI:1.5 to 7.8; in female: APC:3.4%, 95% CI:0.8 to 6.1) were observed in both gender during the study period (p<0.001). Congenital anomalies in Turkey are a major cause of fetal and neonatal death, however, most of the anomalies can be preventable or treatable.