Abstract
C3 and C4 serum level were evaluated in 30 pregnant women which divided into groups: Group A16 (53.3%) (Pregnant women with history of abortion and positive anti toxoplasma IgM antibodies), Group B10 (33%) (Normal pregnancy women with no history of abortion or Toxoplasmosis.), Group C6 (20%) (Pregnant women with history of two abortion and positive anti toxoplasma IgM), group D 10 (33.3%) (Pregnant women with history of only one abortion and positive anti- toxoplasma IgM), group E 4 (13.3%) (Pregnant women with history of only one abortion and negative anti-toxoplasma IgM). The results showed that highest level of both C3 and C4 in women with positive anti toxplasma IgM and history of one or two abortion/abortions while the lowest level of these two complements were in women with negative anti toxplasma IgM even they had one abortion or no abortion. There is significant differences in concentration of C3 ( 189.7 ± 20.3 mg/dl ) and C4 ( 59.3 ± 7.5 mg/dl ) in group A and C3 ( 189.6 ± 17.7 mg/dl ) and C4 ( 63.08 ± 4.7 mg/dl) when compared with group B and E, and the result showed statistical differences in C4 concentration between group C and D at P< 0.05. We conclude that complement was play role in immune response of pregnant women especially against toxoplasmosis that cause abortion to these women.
Highlights
Toxoplasma gondii is an obligate intracellular protozoan that belongs to the phylum Apicomplexa; subclass coccidian can take several different forms: the oocyst; the tachyzoite and the cyst [1]
Out of 30 pregnant, 6 (20) % had history of recurrent abortion 2 abortion and positive anti toxoplasma IgM, 10 (33.3)% had a history of only one abortion and positive antitoxoplasma IgM, 4 (13.3)% had history of one abortion and negative anti- toxoplasma IgM, and 10 (33.3)% normal pregnancy women with no history of abortion or Toxoplasmosis
Significant differences C3 and C4 were noticed between Group A and Group B Group A showed high C3 (189.7 ± 20.3 mg/dl) and C4 level (59.3 ± 7.5 mg/dl) while it was less in Group B, C3 (116.3 ± 19.8 mg/dl) and C4 level (28.2 ± 5 mg/dl) Table (2)
Summary
Toxoplasma gondii is an obligate intracellular protozoan that belongs to the phylum Apicomplexa; subclass coccidian can take several different forms: the oocyst; the tachyzoite and the cyst [1] The infection with this parasite called Toxoplasmosis, the importance of T. gondii as a human pathogen has stimulated a huge number of researches [2], most of the T. gondii infected people being clinically asymptomatic and spontaneous recovery [3, 4]. We choose the pregnant women in this study because toxoplasmosis was showed risk factor for fetus and lead to abortion. C3 and C4 evaluation C3 and C4 concentration were determined by using single radial immune diffusion (Sanofi Diagnostic Pasture) according to the manufacturer's instruction, five μl of serum sample or control were applied.
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