Evaluation of circulatory microRNA-196 levels during the progression of chronic renal (kidney) disease of unknown etiology

Abstract

Chronic renal disease of unknown etiology is prevalent & clinically silent until its late stages at which point patients may suffer significant irreversible damage or mortality in the lack of early screening & intervention. If diagnosed early stage 1-3 the progression of chronic renal disease can be altered and complications reduced. Current diagnosing markers of renal function, serum creatinine, blood urea and uric acid have been shown to be lacking high predictive value. So, there is a need for next generation biomarkers suitable for Chronic renal disease of unknown etiology and should not be influenced by age, sex, nutritional status, current health concern. microRNAs appears to be very stable in tissues & biological fluids even under adverse conditions like extreme pH, long term room temperature storage, multiple freeze thaw cycles & RNAase activity. microRNAs elaborate in renal development, maintenance of renal function & progression of renal disease. miRNA-196 is a renal derived biomarker, extensively distributed in renal, shows an important role in renal diseases & superior to other renal biomarkers. The aim of present study is to evaluate circulatory miRNA-196 during progression of chronic renal disease of unknown etiology.