Abstract
BackgroundOverexpression and enhanced release of vascular endothelial growth factor (VEGF) have been detected in various types of allergic inflammation, including asthma.AimTo further evaluate the pattern of systemic release of VEGF in atopic allergy, free circulating VEGF was measured in patients with persistent allergic rhinitis (PAR).MethodsThe concentrations of VEGF and its soluble receptors (sVEGF-R1 and VEGF-R2) in plasma were measured in patients with PAR sensitized to house dust mites and the healthy subjects.ResultsNo significant differences were found between PAR patients and healthy subjects with respect to plasma levels of VEGF and its receptors.ConclusionsIt seems that free circulating VEGF may not be elevated in PAR patients. Moreover, on the basis of the present study as well as the earlier ones, it appears likely that systemic release of VEGF varies among patients with distinct clinical manifestation of atopy; may depend on severity/activity and the extent of inflammatory response.
Highlights
Overexpression and enhanced release of vascular endothelial growth factor (VEGF) have been detected in various types of allergic inflammation, including asthma
It seems that free circulating VEGF may not be elevated in persistent allergic rhinitis (PAR) patients
We investigated plasma VEGF concentration in patients with allergy to house dust mites, suffering from persistent allergic rhinitis (PAR) in the absence of asthma symptoms
Summary
Overexpression and enhanced release of vascular endothelial growth factor (VEGF) have been detected in various types of allergic inflammation, including asthma. It has been indicated that vascular endothelial growth factor (VEGF) is a multifunctional cytokine, which plays a role in the pathogenesis of immune-inflammatory reactions [1, 2]. VEGF is a powerful enhancer of vascular permeability and its activity is 50,000 times more potent than histamine [3]. VEGF may be released by different cells associated with allergic inflammation of the airways, including mast cells upon activation via the Fcε receptor I (FcεRI) [2, 4,5,6]. It has been demonstrated that dust-mite allergen may stimulate airway cells to increased VEGF
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