Abstract
BackgroundLittle is known about choroidal involvement in anterior uveitis. The aim of our study was to evaluate changes in choroidal thickness and volume in eyes with acute anterior uveitis (AAU) using enhanced depth imaging-optical coherence tomography (EDI-OCT) at baseline and after treatment, which were compared with healthy fellow eyes.MethodsFor the study, 35 individuals with unilateral acute AAU at the first onset were enrolled. Subfoveal thickness and choroidal volume were measured with EDI-OCT in nine Early Treatment of Diabetic Retinopathy Study (ETDRS) subfields before and after the completion of treatment. Moreover, axial length measurements of both eye bulbs were determined by optical biometry.ResultsNo statistically significant differences in choroidal thickness or choroidal volume were detected between AAU eyes at baseline and after treatment and fellow eyes. Positive correlations between the values of anterior chamber flare and absolute CT changes in both temporal and inferior ETDRS fields, as well as in superior outer ring were detected. Negative correlations between age and both choroidal thickness and choroidal volume were detected in AAU eyes at baseline and after treatment, as well as in fellow eyes.ConclusionsEvaluation of the choroid with EDI-OCT does not appear to be a reliable tool for the treatment monitoring of eyes with anterior uveitis.
Highlights
Both the etiology and manifestation of uveitis may vary among individuals
The total time of acute anterior uveitis (AAU) treatment and the interval between optical coherence tomography (OCT) examinations were in the range of 1 to 6 weeks
No significant changes in Visual acuity (VA) of the fellow eyes (FE) or in the intraocular pressure in both eyes were detected at baseline and after the AAU treatment
Summary
Acute anterior uveitis (AAU) is the most common manifestation of all uveitis types according to the International Uveitis Study Group [1, 2], which defined and presented valid nomenclature. Development of optical coherence tomography (OCT) technology showed subclinical involvement of the posterior retina and choroid in some cases of AAU [2, 3]. Involvement of the choroid may cause changes in choroidal thickness (CT) or correlate with lower visual acuity in those patients [3, 4]. The aim of our study was to evaluate changes in choroidal thickness and volume in eyes with acute anterior uveitis (AAU) using enhanced depth imaging-optical coherence tomography (EDI-OCT) at baseline and after treatment, which were compared with healthy fellow eyes
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