Abstract
Evaluation of Chemical Composition, Antibacterial, Antifungal, and Cytotoxic Activity of Laurus nobilis L Grown in Saudi Arabia
Highlights
Medicinal plants are used worldwide to cure many diseases
Acetone extracts had the largest inhibition zone against Streptococcus pnemoniae (37.16 ± 0.23 mm) while ethanol and methanol extract showed the most efficient percentage inhibition against mycelial growth of Alternaria alternata (91.33 ± 0.47; 90.66 ± 0.94).High cytotoxicity was demonstrated by methanol and aqueous extracts (IC50 14.90μg/ml, 24.56 μg/ml), while acetone extracts showed moderate effects on cell inhibition (IC50 41.43μg/ml).The significant activity shown by the bay leaf extracts could be attributed to monoterpene hydrocarbons, oxygenated monoterpenes, phenylpropanoids, phenols, and other important phytoconstituents identified in GC- MS and FTIR studies
Our findings clearly show significant antifungal, antibacterial and cytotoxic activity of solvent extracts of bay leaves, which could be attributed to the presence of wide range of phytochemicals
Summary
Medicinal plants are used worldwide to cure many diseases. Due to the undesirable side effects of modern synthetic pharmaceuticals and the simultaneous increase in microbes with multidrug resistance, traditional herbal approach to cure diseases is in vogue. Saudi Arabia represents one of the most biodiverse areas in the Arabian Peninsula[1]. Tabuk, is located in the Northwest region of Saudi Arabia and is well known for its diverse flora and fauna[2]. Herbal medicine (both native and non-native plants) is an ancient tradition in Saudi Arabia. Plants and their different parts possess a wide array of chemical components, which are used in ethano pharmacological research and have been explored since ages because of their immense benefits
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