Evaluation of changes of global longitudinal strain in patients with coronary artery disease after PCI

Abstract

Recovering blood flow to a coronary stenosis may improve left ventricular (LV) function in patients with coronary artery disease (CAD). However, the reported data about evaluation of LV function post-percutaneous coronary intervention (PCI) in CAD was limited. Purpose of this study was to determine the change in parameters of global longitudinal strain (GLS) in patients with CAD underwent PCI, and to compare the LV function measured by ejection fraction (EF) and global longitudinal strain. We enrolled Patients with CAD who underwent elective PCI. Echocardiographic measurements of LV function by EF as well as by 2D speckle tracking to assess global longitudinal strain were performed in all patients within 24 hours pre- and post-PCI procedure and 1 week later. The LV global longitudinal peak strain average (GLPS-Avg) was calculated from 18 segments measurement. The study included (57.2 ± 6.8 years old). Means of GLPS-Avg pre-, 24 hours and one week post-PCI were −9.58 ± 3.74% and −10,43 ± 4.36% and 16.79 ± 4.98 respectively. Means of EF pre-, 24 hours and one week post-PCI were 42.3 ± 10.1% and 44.5 ± 11.08% and 47.85 ± 11.79%, respectively. The improvement of LV function was more significant statistically when it was measured by GLPS-Avg ( P < 0.0001) than that of EF ( P < 0.001). The improvement of GLPS-Avg was correlated with target vessel revascularization involving left anterior descending artery. Recovery of left ventricular function post-revascularization of coronary artery disease could be detected earlier by either ejection fraction or global longitudinal strain measurements; however the latter is more accurate. Improvement of GLPS is correlated moderately with target vessel revascularisation involving left anterior descending artery.