Abstract
Ceruloplasmin is considered the main copper transport protein which is proposed to have a role in cancer. Ceruloplasmin is an acute phase reactant and antioxidant enzyme, has been found to be increased in sera of patients with several types of cancers including breast cancer.
 The aim of present study was to determine of ceruloplasmin oxidase activity, specific activity, iron concentration in sera of patients with breast cancer and comparing with healthy group, and the ability of using enzyme as a tumor marker for breast cancer.
 This study was performed from November 2018 to January 2019, blood samples were collected from breast cancer patients in Nanakeli Hospital in Erbil city. Study was included (65) female patients with breast cancer and (20) healthy donors as control group. Ceruloplasmin activity, specific activity, serum total protein concentration, serum total iron concentration levels were estimated for all samples by colorimetric methods. 
 The results shown that there was a significant increase in ceruloplasmin activity level for patients with breast cancer ( 227.8 U/L) compared with control group (101.1 U/L) while total protein level for breast cancer patients (6.592 g/dl) showed no significant change compared to control group(7.127 g/dL) likewise the result shown that there was a significant increase in specific activity of ceruloplasmin and total iron concentration level for patients with breast cancer (34.74 U/mg) (334.2 mg/dl) compared to control group (14.14 U/mg) (128.6 mg/dl) The conclusion of this study was the concentration of ceruloplasmin activity, serum total iron concentration and specific activity of ceruloplasmin significantly increase in breast cancer patients while total protein level revealed no significant change.
 Serum ceruloplasmin oxidase activity and specific activity were highly significant elevated in patient group when compared with control group. Also the total iron concentration results showed significant increasing (PË‚0.0001) between of patient with breast cancer and control group.
Highlights
Breast cancer is one of the most common cancers among women around the world, accounting for about 570,000 deaths in 2015 [1]
The results show a significant increase (P0.0001) in the patient group compared with the control group as shown in Table (1)
4.Conclusions According to the results of this study, serum Cp oxidase activity and specific activity were highly significantly elevated in-patient group when compared with the control group
Summary
Breast cancer is one of the most common cancers among women around the world, accounting for about 570,000 deaths in 2015 [1]. The Cp is an acute-phase protein that is typically produced by hepatic cells [7] and is primarily secreted in the plasma [8], whereas Cp mRNA was found in cell lines of breast cancer patients [9]. It is comprised of angiogenesis and neovascularization it has a role in cancer [10]. The relation between the iron concentrations which can cause a high amount of free radicals in breast cancer and ceruloplasmin activity. The ability to use Cp as a tumor marker for the early diagnosis of breast cancer is possible
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