Evaluation of certain pharmaceuticals with hexa-amminecobalt(III) tricarbonatocobaltate(III)—I: Determination of some N-substituted phenothiazine derivatives

Abstract

Hexa-amminecobalt(III) tricarbonatocobaltate(III) (HCTC) has been used for the determination of six N-substituted phenothiazine derivatives. The drugs in 10% v/v sulphuric acid medium were titrated with 5 × 10 −3 M HCTC with visual or spectrophotometric end-point detection. The stoichiometry of the reaction was assumed and a reaction mechanism suggested. The methods were applied to the analysis of dosage forms with results comparable to those given by the official methods.