Abstract
BackgroundRicinus communis (RC) has been used for a long time as natural origin medicine in the treatment of central nervous system ailments. This present study was designed to identify the possible role of Ricinus communis leaves extract against ischemia-reperfusion induced-neurobehavioral changes, oxidative stress, histopathological and cellular modifications in the brain.MethodsSprague Dawley (SD) rats (200–250 g) were induced to bilateral common carotid artery occlusion (BCCAO) for around 30 min later subjected to reperfusion for 24 h to induce cerebral injury by reperfusion. Ricinus communis leaves extract (250 and 500 mg/kg, p.o) was administered continuously for 14 days and on the 15th-day animals were subjected to ischemia-reperfusion injury. Different behavioral tests and biochemical parameters were assessed subsequently.ResultsFourteen days Ricinus communis leaves extract (250 and 500 mg/kg, p.o.) treatment very significantly improved neurobehavioral alterations when compared to control ischemia-reperfusion. Ricinus communis leaves extract (250 and 500 mg/kg, p.o.) kg, i.p. treatment significantly attenuated oxidative damage when compared to ischemia-reperfusion (I/R) group animals. In addition, Ricinus communis leaves extract treatment was well supported histopathologically when compared to the ischemia-reperfusion (I/R) group.ConclusionThe data from this study recommend that treatment with Ricinus communis leaves extract increases the antioxidant protection against BCCAO-induced global cerebral ischemia and demonstrates neuroprotective activity.
Highlights
Cerebrovascular diseases are among the second leading cause of death and the main explanation for adult long-run incapability in developed countries
Effects of Ricinus communis leaves extract on digital grip strength meter of ischemia-reperfusion injured rats The ischemic reperfusion rats produced a significant reduction in grip strength 0.4181 ± 0.011 lbf when compared to Sham group 0.85 ± 0.122 lbf
The earlier reports support that the Ricinus communis has potent antioxidant activity, its seeds may be proved as neuroprotective against focal ischemia-reperfusion induced brain injury, so leaf was chosen for the present study
Summary
Cerebrovascular diseases are among the second leading cause of death and the main explanation for adult long-run incapability in developed countries. Among minutes of blood vessels occlusion, brain tissue develops a shortage of aldohexose and oxygen, and the acidic byproducts of metabolism accumulate. This loss of substrate and reduction in pH level ends up in stopping the electron transport chain activity among mitochondria, which ends up in a very speedy decline in Adenosine triphosphate (ATP) concentration. Ricinus communis (RC) has been used for a long time as natural origin medicine in the treatment of central nervous system ailments This present study was designed to identify the possible role of Ricinus communis leaves extract against ischemia-reperfusion induced-neurobehavioral changes, oxidative stress, histopathological and cellular modifications in the brain
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