Evaluation of central nervous system depressant activity of methanolic and petroleum ether extract of &lt;em&gt;Manilkara zapota&lt;/em&gt; leaves (in vivo)

Manirujjaman ,Trudi Collet

doi:10.5138/09750185.1896

Abstract

The purpose of this study was to examine the central nervous system (CNS) -depressant activity of methanolic and petroleum ether extracts of leaves obtained from Manilkara zapota (Sapotaceae) in vivo. CNS-depressant action was evaluated by observing the effects of plant extracts on both exploratory and spontaneous locomotor activity in mice using open field and hole cross tests respectively. The extracts were found to exhibit CNS-depressant activity in a dose-dependent manner. In the open field test, both the methanolic and petroleum ether extracts reduced the exploratory behavior of mice significantly (p&lt;0.05). Although the extracts reduced locomotor activity in the hole cross test, the results were found to be insignificant. Overall, these findings indicate that both types of extracts derived from M. zapota leaves possess CNS-depressant activity.

Highlights

Manilkara zapota, an evergreen, glabrous tree belonging to the Sapotaceae family, grows abundantly throughout Bangladesh in lowland rainforest to a maximum height of 15 metres
The methanolic and petroleum ether extracts at various doses significantly decreased (p
Only the petroleum ether extract at a concentration of 250 mg/kg and both methanolic extracts (250 and 500 mg/kg) were shown to elicit a significant decrease in overall movement (p

Summary

Introduction

An evergreen, glabrous tree belonging to the Sapotaceae family, grows abundantly throughout Bangladesh in lowland rainforest to a maximum height of 15 metres. Common to India, the tree can be found in Mexico and Central America [1,2]. Very little scientific investigation with regards to its chemical constituents or biological effects has been performed on this species. The leaves of the plant are used to treat diarrhea, coughs and colds [4]. They are reported to possess antimicrobial activity against several different species of bacteria [5, 6]. Given the diverse range of pharmacological effects, this study aimed to investigate in vivo, the central nervous system (CNS) -depressant potential of M. zapota leaf extracts

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Conclusion