Abstract
ABSTRACTPurpose: To evaluate the normative data of macular thickness and retinal nerve fiber layer thickness (RNFL) among normal subjects using spectral domain optical coherence tomography (OCT).Materials and methods: Normal subjects presenting to a tertiary medical hospital were included in the study. All patient underwent clinical examination followed by study of macular thickness and RN FL thick ness by spectral domain Topc on OCT. The data was collected and analyzed for variations in gender and age. The data was also compared with available literature.Results: Total numbers of patients enrolled in the study were 154 (308 eyes). Numbers of males were 79 (158 eyes) and numbers of females were 75 (150 eyes). The mean age among males was 42.67 ± 12.15 years and mean age among females was 42.88 ± 11.73 years.Overall the mean mac ular thickness (central 1 mm zone) with SD - OCT was 241.75 ± 17.3 microns. The mean macular volume was 7.6 cu. mm ± 0.33. On analysis of the RNFL thickness, we observed that the RNFL was thickest in the inferior quadrant (138.58) followed by superior (122.30) nasal (116.32) and temporal quadrant (73.04).Gender-wise comparison of the data revealed no statistically significant difference for age, macular thickness parameters, volume and RFNL values except outer temporal thickness among males and females. No age-related difference was noted in the above parameters. On comparison with available norma tive data from India and elsewhere, we found significant variations with different machines.Conclusion: The study is the first to provide normative data using SD-OCT from central India. The data from spectral domain OCT correlated well with the values obtained from similar studies with SD - OCT. Values obtained from time domain OCT machines are different and are not comparable.How to cite this article: Agarwal P, Saini VK, Gupta S, Sharma A. Evaluation of Central Macular Thickness and Retinal Nerve Fiber Layer Thickness using Spectral Domain OpticalCoherence Tomography in a Tertiary Care Hospital. J Curr Glaucoma Pract 2014;8(2):75-81.
Highlights
Optical coherence tomography is a standard noninvasive diagnostic test today to visualize the morphology of retina
Total numbers of patients enrolled in the study were 154 (308 eyes)
On analysis of the retinal nerve fiber layer thickness (RNFL) thickness, we observed that the RNFL was thickest in the inferior quadrant (138.58) followed by superior (122.30) nasal (116.32) and temporal quadrant (73.04)
Summary
Optical coherence tomography is a standard noninvasive diagnostic test today to visualize the morphology of retina. Central macular thickness can be measured with the OCT and correlated with clinical examination and visual function.[1,2] retinal nerve fiber layer thickness (RFNL) around the disc (peripapillary RFNL) can be measured with the OCT and correlated with the health of neural retinal rim of the optic nerve head and visual fields of the patient.[3,4] With evolution and refinement of technology we have moved from time domain to spectral domain OCT This has lesser image acquisition time and provides high resolution images which help us delineate pathology from normal tissues.[5,6,7,8] There are very few large studies on the normative data for macular thickness using the spectral OCT. Most of the studies of normative data of macular thickness and retinal nerve fiber thickness (RFNL) were done in northern[14,15]
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