Evaluation of CDC6 Expression in Triple-Negative Breast Cancer and its Prognostic Significance

Abstract

ABSTRACT Background: Triple-negative breast cancer (TNBC) leads to high morbidity and poor prognosis due to high proliferation and metastasis. Cell division cycle 6 (CDC6) is one of the genes involved in cell division and is significantly upregulated in TNBC. There is not much information available to understand whether CDC6 can be used as a prognostic marker in TNBC. Methods: In this study, BC-GenExMiner, NetworkAnalyst, GeneMania, GEPIA, COSMIC, cBioPortal, STRING, and FunRich were used to investigate the expression of CDC6 gene. Furthermore, survival analysis to correlate the gene expression was carried out using the Kaplan-Meier plotter. Results: The results showed that mRNA levels of CDC6 were significantly higher in TNBC compared to healthy and other types of breast cancer, and high expression levels were also associated with increased TNBC proliferation. The survival analysis showed that increased mRNA levels of CDC6 in all TNBC patients were associated with a poor prognosis for relapse-free survival. Conclusion: The findings of the current study indicate that CDC6 may be used as a possible prognostic biomarker for TNBC. However, further studies are required to check the effects of CDC6 on the progression and pathogenesis of TNBC.