Abstract
The aim of the study was to assess the carbohydrate and lipid metabolism disturbances as well as weight in children after brain tumors treatment. The study included 33 boys (53.2%) and 29 girls (46.8%) aged 11.6 ± 3.9. 22 patients underwent treatment for tumors of hypothalamic-pituitary(h-p) area: IA–surgery(19/22); IB–surgery and radiotherapy(3/22). 40 patients were treated for tumors outside the h-p area: IIA– with surgery, chemo-and radiotherapy(22/40); IIB–only with surgery(15/40); IIC–patients treated for optic nerve glioma with chemotherapy(3/40). BMI was assessed before and after the treatment. OGTT, HbA1c, lipid profile and WHtR after treatment were assessed. Indices of insulin resistance: HOMA-IR, Quickie, Matsuda and de Fronzo were calculated. 63% overweight/obese patients of IA-group and 27% of IIA-group were observed. Hyperinsulinemia was noted in 44% of IA-group, 20% of IIA-group, and insulin resistance in 38% of IA and 15% of IIA. DM2 was diagnosed in 1 patient of IA-group, IFG in 1 patient of IIB, IGT in 1 patient of IA and 1 patient of IIC. Dyslipidemia was noted in 47% of IA-group, elevated level of LDL-cholesterol in 30% of IIA-group. The excessive weight gain, hyperinsulinemia and dyslipidemia were observed primarily in children treated for hypothalamic-pituitary tumors.
Highlights
Central Nervous System (CNS) neoplasms are the most common type of solid tumors in children and the second type of all children neoplasms after leukemias
CNS neoplasms diagnosed by cytology included: gliomas in 23 patients; MB/Primitive Neuroectodermal Tumor (PNET) (11 patients), craniopharyngioma (18 patients), ependymoma in 3 patients and other types of tumor in 7 patients. 59 children had surgical treatment
The rest of GHdeficient patients in IIA-group remained under observation because of greater risk of tumor recurrence
Summary
Central Nervous System (CNS) neoplasms are the most common type of solid tumors in children and the second type of all children neoplasms after leukemias. A significant improvement in the treatment of this condition was possible due to development of neurosurgery, radiotherapy and chemotherapy. Majority of brain tumor survivors present chronic complications due to neoplastic process and oncology management [1,2]. An assessment of abnormalities of carbohydrate metabolism and its etiology in patients after brain tumors treatment is still an unacknowledged area of interest. The aim of the study was to assess the type and the frequency of carbohydrate and lipid metabolism disturbances as well as weight in children after brain tumors treatment
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