Abstract
Twelve groups of six rabbits per group were treated with nicotine, caffeine, ouabain, hypercholesterolemic diet, and various combinations of these for 24 weeks. Systolic blood pressures and coagulation times were obtained at 4-week intervals, and a histopathological examination of the hearts was made at death or sacrifice. Treatments including either nicotine or cholesterol significantly reduced the coagulation times. Most nicotine-treated groups demonstrated increases in systolic pressures. While myocarditis was observed in several of the animals receiving multiple treatments, such treatments did not increase the incidence or severity of coronary atherosclerosis.
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