Abstract
The effects of several caffeic acid analogues isolated from Salviae Miltiorrhizae Radix (Salvia miltiorrhiza Bunge) on the cultured renal epithelial cell line, LLC-PK1, were studied. Incubation of the cells with different concentrations of these compounds for 48 h markedly suppressed lactate dehydrogenase leakage, which was elicited when the cells were exposed to hypoxia/re-oxygenation or cephaloridine. The most active compounds were magnesium lithospermate B and lithospermic acid B, two tetramers of caffeic acid, followed by lithospermic acid (trimer) and rosmarinic acid (dimer). Caffeic acid showed poor activity. These results indicate that caffeic acid analogues, in particular magnesium lithospermate B and lithospermic acid B, exert a direct protective effect on renal cells.
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