Abstract
<b>Background and Objective:</b> The entries of trace elements into marine invertebrates are mainly in particulate form whereas the exits to the sea concern dissolved forms so that sea waters contain both dissolved and particular forms of the same element. The objective of this study is to detect how <i>Cnemidocarpa amphora</i> detoxifies cadmium and lead. <b>Materials and Methods:</b> <i> </i>This sea squirt is collected from Ras El-Tin beach of the Mediterranean Sea at Alexandria, Egypt from June-August, 2018-2019. Contamination of the sea squirt is carried out with CdCl<sub>2</sub> exposure (500 μg L<sup></sup><sup>1</sup>) for 7 and 21 days. <b>Results:</b> The first detoxification mechanism is immobilizing cadmium in the absorbent organs in a stable and inert state (phosphate). The second one is the most important which involves hemocytes with natural zinc storage in the synthesis of metallothioneins (MTs) which complexes cadmium. <b>Conclusion:</b> Safe our environment to save human lives. Sea squirts react against the chromate by incorporating it into the mucous secretions of the GI tract. The dissociation of a part of the compound releases assailable chromium and lead which cause general tissue contamination. Lead chromate has harmful effects on sea squirts than chromium and lead.
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