Abstract
Objective: C-Reactive Proteins (CRP) is an important marker of Sub-clinical infection in cases of Premature Rupture of Membrane (PROM).The aim of present study was the evaluation of CRP from the patients attending in our hospital with premature rupture of membrane.
 Materials and Method: A total of 32 patients of Preterm, Premature rupture of membranes and 32 patients preterm with intact membranes as a control, between 28-36 weeks of gestation were included in the study.
 Results: The Sensitivity and specificity of CRP determination was found to be 78.12% each as an early predictor of subclinical chorioamnionitis. TLC had a low sensitivity of 22% and specificity of 65% in detecting histological chorioamnionitis (HCA).
 Conclusion: CRP estimation is a simple, reliable, quite affordable and reasonably marker for the detection of early chorioamnionitis.
 Keywords: PROM, CRP, Chorioamnionitis, Sensitivity, Specificity
Highlights
C- reactive protein is an acute phase protein, produced by hepatocytes and secreted in the blood after inflammation, infection, trauma, necrosis, malignancy, and allergic reactions
Objective: C-Reactive Proteins (CRP) is an important marker of Sub-clinical infection in cases of Premature Rupture of Membrane (PROM).The aim of present study was the evaluation of CRP from the patients attending in our hospital with premature rupture of membrane
Acute inflammation of the membranes and chorion of placenta is known as Chorioamnionitis or Intra-amniotic infection and it is typically due to ascending polymicrobial bacterial infection due to premature rupture of membranes
Summary
C- reactive protein is an acute phase protein, produced by hepatocytes and secreted in the blood after inflammation, infection, trauma, necrosis, malignancy, and allergic reactions. CRP level can increase 10,000-fold from less than 50 μg/l to more than 500 mg/L after stimulus and production and concentration of CRP increase to 5 mg/L by 6 hours and peak at 48 hours, which increases with inflammation. It cans double every 8 hours and reaches its peak at 36 to 50 hours. Premature rupture of membrane (PROM) is one of the most common underlying causes of preterm delivery, stillbirth and neonatal sepsis, chronic lung disease, Brain injury leading to cerebral palsy, other neurodevelopment disability and perinatal death [1,5,6]
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