Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multistep testing approach in French-Canadian families with high risk of breast and ovarian cancer

Jacques Simard ,H Malouin,C Samson,Sean V Tavtigian ,Louis Houde ,Daniel Sinnett ,Loris Bernard ,Hélène Vézina ,Anne Marie Moisan ,Marie Plante ,Louise Provencher ,Roxane Pichette ,Patricia Voyer ,Paul Bessette ,Jean‐Pierre Lépine ,Michel Dorval ,Bartha Maria Knoppers ,Douglas F Easton ,Rachel Laframboise ,Yann Joly ,Denise Avard ,Gilles Leblanc ,Peter J Bridge ,Josée Rhéaume ,Martine Tranchant ,Marie-Pier Lajoie ,Martine Dumont ,Valérie Gaborieau ,Francine Durocher ,Carl Brousseau ,Jean Parboosingh ,Béatrice Godard ,Jocelyne Chiquette ,David E Goldgar

doi:10.1136/jmg.2006.044388

Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multistep testing approach in French-Canadian families with high risk of breast and ovarian cancer

Jacques Simard , H Malouin + Show 32 more

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https://doi.org/10.1136/jmg.2006.044388

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Journal: Journal of Medical Genetics	Publication Date: Aug 11, 2006
Citations: 75

Affiliation: Centre Hospitalier Universitaire de Québec, Université Laval, Université du Québec à Chicoutimi, International Agency For Research On Cancer, Hôpital du Sacré-Cœur de Montréal, Hôtel-Dieu de Québec, Hôpital du Saint-Sacrement, Cégep de Jonquière, Centre Hospitalier Universitaire de Sherbrooke, Cégep de Rimouski, Université de Montréal, Cancer Research UK, University of Cambridge, Alberta Children's Hospital, University of Utah

#Manchester Scores #Testing For Mutations In BRCA1 + Show 8 more

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Abstract

Background and objective: In clinical settings with fixed resources allocated to predictive genetic testing for high-risk cancer predisposition genes, optimal strategies for mutation screening programmes are critically important. These depend...

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