Abstract
Objective: To perform a clinical and histological evaluation, characterizing and proving the feasibility of the use of beta tricalcium phosphate (HA/βTCP) bioceramics as a bone defect repair material, comparing it with autogenous bone and blood clot in terms of osteoinductive, conductive, and genic capacities. Material and Methods: The experiment was based on 3 critical defects in the mandible of 11 New Zealand rabbits. The defects were filled with HA/βTCP bioceramics and autogenous bone, respectively, collected and ground during the development of defects and blood clots. The animals were euthanized after the 90-day experiment and samples were collected for histomorphological examination. To evaluate differences between the groups, a one-way analysis of variance (ANOVA) was performed with Tukey’s post hoc test. An αvalue lower than 0.05 was considered statistically significant. Results: Microscopy revealed the presence of osteoblasts, osteoclasts, and osteocytes associated or not associated with the presence of mature or immature bone. All the studied materials presented bone neoformation in all cases, with the presence of mature and immature bone. Regarding the presence of HA/βTCP bioceramic residual material, the same was found in 7 of 11 slides. Conclusion: HA/βTCP bioceramics were shown to be a biocompatible bone substitute, with osteoinductive and osteoconductive characteristics, accelerating the process of new bone formation when compared with autogenous and blood clotted bone, thereby showing promise for bone defect repair with safety and efficacy.
Highlights
Much effort has been made to find solutions to correct bone defects for placing osteointegration implants
The defects were filled with HA/βTCP bioceramics and autogenous bone, respectively, collected and ground during the development of defects and blood clots
It has been demonstrated that βTCP bioceramics is a material with properties that can promote osteoinduction, i.e., the capacity to store proteins and cells that are viable, specific, and particular to the individual receiving the implant; allowing natural bone neo-formation and biocompatibility, with problems restricted to its accelerated absorption [1,2]
Summary
Much effort has been made to find solutions to correct bone defects for placing osteointegration implants. Another study performed a histological and histomorphometric analysis of autogenous bone versus βTCP bioceramics alone in 20 cases of bilateral sinus lift. ΒTCP bioceramics alone were placed, and on the other autogenous bone, in each patient It was found no significant difference in the histologic and histomorphometric analyses in the experimental and control groups after 6 months; being considered a good material for this type of treatment [5]. The evaluation was performed through sequential radiographs, tomography, histology, immunohistology, and microradiography to analyze the density and percentage of bone growth They concluded that there was excellent integration and significant bone regeneration besides evident osteoclastic biomaterial reabsorption. The objective of this study was to perform a clinical and histological evaluation, characterizing and proving the feasibility of the use of HA/βTCP bioceramics as a bone defect repair material, comparing it with autogenous bone and blood clot in terms of osteoinductive, conductive, and genic capacities
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
