Evaluation of bone mineral density in patients with gestational diabetes mellitus by ultrasonic bone mineral density measurement combined with Vitamin-D deficiency and analysis of influencing factors.

Lulu Han,Shenghai Wang,Zhihong Li,Jingjing Ma

doi:10.12669/pjms.38.4.5090

Lulu Han, Shenghai Wang + Show 2 more

Open Access

https://doi.org/10.12669/pjms.38.4.5090

Copy DOI

Abstract

Objectives:To investigate the evaluation of bone mineral density (BMD) in patients with gestational diabetes mellitus (GDM) by ultrasonic bone mineral density measurement combined with Vitamin-D deficiency and its influencing factors.Methods:A total of 100 patients with gestational diabetes mellitus (GDM) admitted to our hospital from January 2017 to December 2020 were selected as the GDM group, and another 100 pregnant volunteers who underwent physical examination in our hospital were selected as the healthy control group. The levels of triacylglycerol (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), glycated hemoglobin (HbA1c), fasting insulin (FINS), C-peptide, procollagen, parathyroid hormone (PTH), serum calcium, 25-hydroxyvitamin-D3 (25-OH-D) and ultrasonic BMD Z-score were determined and compared between the two groups. Moreover, the effects of different levels of 25-OH-D on the above indexes were compared, and multivariate logistic regression analysis was performed.Results:Compared with the healthy reference group, the levels of TG, TC, LDL-C, PTH, HbA1c, FINS and C-peptide of GDM group were significantly increased (P < 0.05), while BMD Z-score and 25-OH-D levels were significantly decreased. In the GDM group, the lower the 25-OH-D levels, the higher the FPG, HbA1c and FINS levels and the lower the serum calcium level and BMD Z-score, with statistically significant differences (P < 0.05). Multivariate logistic regression analysis showed that 25-OH-D was an independent risk factor affecting BMD in patients with GDM (P<0.05).Conclusions:Patients with GDM have lower BMD and 25-hydroxyVitamin-D3 levels. Measurement of BMD and 25-hydroxyVitamin-D3 levels can help assess the progression of GDM. BMD has a close bearing on Vitamin-D deficiency in patients with GDM.

Highlights

Evaluation of bone mineral density in patients with gestational diabetes mellitus by ultrasonic bone mineral density measurement combined with Vitamin-D deficiency and analysis of influencing factors
Gestational diabetes mellitus (GDM) is a type of impaired glucose tolerance with varying degrees that occurs during gestation period or first occurs during pregnancy.[1]
Vitamin-D is an essential substance for glucose to stimulate insulin secretion and maintain normal glucose tolerance under physiological conditions, and insulin resistance is an important cause of diabetes.[6]

Summary

Introduction

Gestational diabetes mellitus (GDM) is a type of impaired glucose tolerance with varying degrees that occurs during gestation period or first occurs during pregnancy.[1]. GDM is a common metabolic disorder during gestation period, which seriously threatens the health of pregnant women and newborns. Pregnant women with GDM often have lumbago in different parts and degrees, which may be related to abnormal bone metabolism caused by abnormal glucose metabolism.[2]. Pak J Med Sci March - April 2022 (Part-II) Vol 38 No 4 www.pjms.org.pk 933 women’s hormone levels change significantly, and their needs for various micronutrients gradually increase, making them vulnerable to Vitamin-D deficiency.[3]. Pregnant women who cannot supplement Vitamin-D in time may suffer from numerous adverse effects, such as Vitamin-D deficiency, bone loss and bone density reduction, which in turn affects the related immune response.[5]. Monitoring Vitamin-D level is crucial for GDM patients

Objectives

Methods

Results

Conclusion