Abstract
Objective: To evaluate the efficacy of dynamic multi-slice spiral computed tomography (MSCT) for providing quantitative information about blood flow patterns of solitary pulmonary nodules (SPNs) and differentiating solitary pulmonary nodules (SPNs). Methods: 37 patients with SPNs (diameter≤4 cm; 24 with maliagnant; 6 with benign; 7 with inflammatory) underwent multi-location dynamic contrast material-enhanced (90 mL, 4 mL/s) serial CT. Peak height and ratio of peak height of the SPN to that of the aorta were measured. Precontrast attenuation was recorded. Perfusion was calculated from the maxi- mum gradient of the time-attenuation curve and the peak height of the aorta. Results: Peak heights of malignant (37.98 HU±17.97) and inflammatory (43.86 HU±14.20) SPNs were significantly higher than those of benign SPNs (5.65 HU±6.43) (P 0.01). SPN-to-aorta ratio in inflammatory SPNs (20.78%±4.14) was significantly higher than that in benign (2.00%±2.26) and malig- nant (14.63%±6.22) SPNs (P 0.01). Conclusion: MSCT provides quanti- tative information about blood flow patterns of solitary pulmonary nodules (SPNs) and is applicable diagnostic method for differentiating SPNs.
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