Abstract
BackgroundAsthma is a common respiratory disorder; some data were present on the correlation between increased levels of some elements and the risk of asthma development. It was aimed to evaluate the levels of 13 selected blood and tooth elements (magnesium, phosphorus, calcium, chromium, manganese, iron, copper, zinc, strontium, molybdenum, cadmium, lead, mercury) in a well-controlled asthma group and the control group.MethodsDuring the study period, 17 asthma patients and 26 age and gender-matched healthy children donated shed deciduous teeth having neither decay nor filling and enrolled for the study. The element levels in blood and teeth matrixes were analyzed with inductively coupled plasma mass spectrometry. Differences in blood and tooth elements in groups were evaluated with generalized linear models after adjusting confounding factors.ResultsAfter adjusting the child’s “z scores of body mass index for age”, history of iron deficiency anemia, and status of parental smoking, the generalized linear model revealed significantly lower tooth magnesium levels, lower blood zinc levels, and lower blood zinc/copper ratio in the asthma group than the control group (p = 0.042, p = 0.034, p = 0.002, respectively). Other studied elements for tooth and blood matrixes were similar in groups.ConclusionOur study revealed some differences in tooth and blood element levels in the asthma group. Further studies on zinc and magnesium levels of severe asthma cases are necessary for the interpretation of the results.
Highlights
Asthma is a common chronic respiratory disorder with airway inflammation, and the prevalence of asthma has increased in the last years
The main reason for asthma is a shift in the T helper 1 (Th1)/T helper 2 (Th2) balance towards a Th2 response leading to inflammation, and the risk of asthma development due to dysregulation of these metal homeostasis has been claimed recently [1, 2, 5]
The asthma group and the control group were compared in terms of WAZ, HAZ, gestational length, and maternal age were found to be similar (p > 0.05)
Summary
Asthma is a common chronic respiratory disorder with airway inflammation, and the prevalence of asthma has increased in the last years. It is supposed that the increase in the prevalence of asthma is related to the additional effects of environmental factors and lifestyle changes in addition to the genetic tendency [1,2,3,4] Elements such as calcium (Ca), phosphorus (P), iron (Fe), zinc (Zn), magnesium (Mg), copper (Cu), cobalt (Co), chromium (Cr), manganese (Mn), molybdenum (Mo), The main reason for asthma is a shift in the T helper 1 (Th1)/T helper 2 (Th2) balance towards a Th2 response leading to inflammation, and the risk of asthma development due to dysregulation of these metal homeostasis has been claimed recently [1, 2, 5]. It was aimed to evaluate the levels of 13 selected blood and tooth elements (magnesium, phosphorus, calcium, chromium, manganese, iron, copper, zinc, strontium, molybdenum, cadmium, lead, mercury) in a well-controlled asthma group and the control group
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