Abstract
1126 children, 2 months to 3 years old, received a single intranasal dose of 10 4, 10 6, or 10 7 TICD 50 of cold adapted (ca) A/Kawasaki/9/86 (H1N1) and A/Beijing/352/89 (H3N2) or placebo, in a double blind, placebo-controlled, safety and immunogenicity trial. No reactogenicity attributable to vaccine was demonstrated. A single bivalent 10 6 or 10 7 dose produced high rates of seroconversion to H1N1 (77%) and H3N2 (92%) in seronegative children > 6 months old; serologic responses were lower to H1N1 ( P < 0.001) and H3N2 ( P = 0.01) in younger infants. A single 10 6 dose of bivalent ca influenza A vaccine can be immunogenic in children, but response is age dependent.
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