Abstract
Evaluation of biomarker activity in gingival crevicular fluid during short-term orthodontic treatment: comparison between mesial and distal sites
Highlights
During orthodontic tooth movement, periodontal tissues respond rapidly to mechanical stress with consequent metabolic changes that allow tooth movement
alkaline phosphatase (ALP), AST and lactate dehydrogenase (LDH) activity in gingival crevicular fluid (GCF) measured at the control canine (CC) showed no significant changes during treatment as a result of lack of orthodontic force
Before application of orthodontic force, there were no significant differences in the ALP, AST and LDH activity between the distal and mesial measurement sites of the test canine (TC)
Summary
Periodontal tissues respond rapidly to mechanical stress with consequent metabolic changes that allow tooth movement. This process triggers a cascade biological process involving acute inflammatory response in periodontal ligament and alveolar bone remodeling (Dudic et al, 2006; Kumar et al, 2019). The aim of our study was to assess GCF activity of ALP, AST and LDH from mesial and distal sides of the teeth during the short-term orthodontic treatment.
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