Abstract
To evaluate the biological safety of composite materials based on poly(L-lactide-co-glycolide) (PLGA) and bioactive glass (BG), which have a potential application in tissue engineering, the in-vivo biological properties were investigated by applying the micronucleus test, acute systemic toxicity test, haemolytic test and pyrogen measurement. The results indicated that the PLGA/BG composite showed no genetic toxicity; there was no toxicosis or death observed in the acute systemic toxicity test. The haemolytic test suggested that the PLGA/BG composite, with a haemolytic index of 0.281%, did not have an obvious haemolytic reaction. In addition, the PLGA/BG composite materials showed no pyrogen reaction. Therefore, PLGA/BG composite materials could be promising candidate biomedical materials for bone tissue engineering.
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