Abstract
The aim of the investigations was to evaluate benefits of the directed transport system - a nanocomposite, based on cisplatin and magnetite combined with local action of constant magnetic field on the tumor, in experiments in vivo in animals with transplantable Guerin carcinoma. Animals were divided into 5 groups according to the type of agent. We showed that nanocomposite in combination with static magnetic field exercises more prominent anti-tumor activity than cisplatin alone. It should be noted that regardless of the therapeutic agent, in Guerin carcinoma we observed </
Highlights
In the past two decades nanotechnologies made great contribution into biological and medical sciences all over the world [1,2,3]
The aim of the investigations was to evaluate benefits of the directed transport system—a nanocomposite, based on cisplatin and magnetite combined with local action of constant magnetic field on the tumor, in experiments in vivo in animals with transplantable Guerin carcinoma
We showed that nanocomposite in combination with static magnetic field exercises more prominent anti-tumor activity than cisplatin alone
Summary
In the past two decades nanotechnologies made great contribution into biological and medical sciences all over the world [1,2,3]. This includes experimental and clinical oncology because cancer morbidity and mortality are still high and do not reduce [4]. Nanotechnology is an interdisciplinary science which allows to study interaction of nanoparticles (NPs) with biomolecules on the cell surface as well as inside the cell. This is actual problem in experimental and clinical oncology. Tumor targeted NPs can enter tumor cells from extracellular space [11,12]
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