Abstract
Evaluation of biokinetics and dosimetry in [131I]-NaI therapies: whole-body images quantification versus lower limb region
Highlights
Radioiodine therapy with iodine-131 (131I) is the most commonly performed radionuclide therapy in Nuclear Medicine[1]
Internal dosimetry is a method capable of giving information about the dose of radiation to be absorbed by internal organs, making possible an individualized and safe protocol for the treatment of each patient, this dosimetry is not routinely used in the nuclear medicine clinics and the patients indicated to the radioiodine therapy are treated with fixed or semifixed activities of 131I, independently of the individual biokinetic characteristics presented by those patients[3]
As the current dosimetric protocol can be performed by delimiting a region of interest (ROI) in whole body images to evaluate the biokinetics and absorbed dose by the patient, the objective of this study was to analyze the possibility of this measurement be restricted to only one thigh region
Summary
Radioiodine therapy with iodine-131 (131I) is the most commonly performed radionuclide therapy in Nuclear Medicine[1]. Internal dosimetry is a method capable of giving information about the dose of radiation to be absorbed by internal organs, making possible an individualized and safe protocol for the treatment of each patient, this dosimetry is not routinely used in the nuclear medicine clinics and the patients indicated to the radioiodine therapy are treated with fixed or semifixed activities of 131I, independently of the individual biokinetic characteristics presented by those patients[3] The exception to this scenario is usually in cases of patients with metastatic disease, when it is necessary to evaluate the dose to be received by the internal organs. The bone marrow is one of the most important organs for the dosimetric calculation, since it is highly radiosensitive and should receive a maximum of 2 to 3 Gy[4,5]
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