Abstract
e20698 Background: Multifactorial pathogenesis is involved in anemia of cancer patients. However, conventional laboratory evaluation such as iron, TIBC and ferritin has only limited value for distinguishing the causes of anemia. As more relevant biomarkers, hepcidin contributes to the development of anemia of chronic disease (ACD), and soluble transferring receptor (sTfR)is a good indicator of iron restricted erythropoiesis in patients with inflammation. Methods: Since July 2008, serum samples from cancer patients were achieved and stored at -70’C in Samsung Medical Center. Twenty-nine stored frozen serum samples from 4 types of cancer (gastric cancer, biliary tract cancer, lung cancer, and lymphoma) were used to analyze ferritin, soluble transferring receptor (sTfR), CRP, and hepcidin with commercial ELISA kits. For the analysis, anemia was defined as hemoglobin (Hb) ≤11g/dL. Results: The median age of all patients was 57 (27-72) years. There were 11 gastric cancer (37.9%), 6 biliary tract cancer (20.7%)...
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