Evaluation of biochemical markers in diabetic rats fed diets supplemented with fruit purees

Abstract

ABSTRACTIn this work, the effect of intake of fruit purees (guava-strawberry, guava-blackberry, guava-soursop, guava-passion fruit) by diabetic rats on reduction of plasma glucose and inflammation biomarkers was evaluated. Consumption of fruit purees in addition to a standard diet was associated with a reduction in body weight (20%), control of glucose metabolism, by decreasing plasma glucose (62.1%). We found a significant reduction in activities of alanine aminotransferase (49.41%), alkaline phosphatase (57.25%) and ϒ-glutamyl transferase (76%), which are useful markers of inflammatory process in the liver. Purees did not alter lipid metabolism and a remarkable improvement in liver morphology was observed. The diets order with the best beneficial effects was diet supplemented with guava-blackberry > guava-strawberry > guava-passion fruit > guava-soursop fruit. Consumption of fruit purees represent a therapeutic alternative by diabetic individuals.