Abstract
Evaluation of biochemical and reproductive biomarkers on gestational period in immunosuppressed Wistar rats with Cyclosporin
Highlights
The pregnancy period involves a lot of biological changes, and the use of medication must be taken with extremely caution, especially because of its implications for maternal and fetal health, involving biochemical and reproductive functions in maternal organism
The objective of this study was to evaluate the effects of immunosuppressive therapy with Cyclosporine A in reproductive and biochemical profile in pregnant Wistar rats. It was observed a progressive increase in body weight during the pregnancy in all groups compared to the first day
The glycemic curve generated by OGTT show the timepoint of 120 min of CLP1 group was increased related to other groups
Summary
The pregnancy period involves a lot of biological changes, and the use of medication must be taken with extremely caution, especially because of its implications for maternal and fetal health, involving biochemical and reproductive functions in maternal organism. The Cyclosporin A (CLP) is used to avoid possible rejection of transplanted tissues, being one of most immunosuppressant used
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