Abstract
Mushrooms possess wide array of biologically active secondary metabolites and have been traditionally used for their medicinal properties. Exopolysaccharide (EPS) is one of such bioactive metabolites. The bioactive attributes and emulsification capabilities of the exopolysaccharides produced by a novel brown-rot fungus Fomitopsis meliae AGDP-2 under submerged fermentation has been thoroughly investigated in the present study. Exopolysaccharide displayed anti-oxidant activities in dose dependent manner with the maximum scavenging of ABTS radicals (42.45%), DPPH radicals (75.34%), Hydroxyl radicals (63.64%), Superoxide anion radical (76.54%) and Ferric Reducing Antioxidant Power with IC50 value of 231µg/mL. Additionally, evaluation of anti-proliferative properties revealed that EPS significantly inhibited the proliferation of HepG2 and HT-29 cancer cells followed by moderate inhibition of HeLa and MCF-7 cancer cell lines and quite less inhibition of L-132 and KB cell lines. The IC50 values of EPS for the abovementioned cell lines are 9.465µg/mL, 11.25µg/mL, 38.98µg/mL, 87.78µg/mL, 2061µg/mL and 2361µg/mL respectively. Moreover EPS also possess good anti-microbial as well as anti-biofilm properties. The studies on emulsification potential described that EPS is good emulsifier of different vegetable oils and the emulsion formed was quite stable up to 144h.
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