EVALUATION OF BENEFICIAL EFFECTS OF LINUM USITATISSIMUM IN CONGESTIVE HEART FAILURE

Pravin Tirgar,Limbasiya Kalpesh

doi:10.22159/ijpps.2017v9i10.20534

Abstract

Objective: Evaluation of beneficial effects of the seed of Linum usitatissimum in congestive heart failure.Methods: Methanolic extract of seeds of Linumusitatissimum (MELU) was prepared using soxhlet apparatus and oil of seed of Linumusitatissimum (OLU) was isolated using Clevenger apparatus. The positive inotropic action of methanolic extract of seeds of Linum usitatissimum was evaluated using Langendorff’s assembly (in vitro study). Beneficial effects of methanolic extract and oil of seeds of Linum usitatissimum were carried out by doxorubicin (1 mg/kg, i. p. within 3 w) to induce congestive heart failure (in vivo study). Parameters like electrocardiogram (ECG) recording and cytosolic Ca2+level and histopathology of the heart were carried out. In same study diuretic action was evaluated using Lipschitz model.Results: Methanolic extract of seeds of Linum usitatissimum showed significantly increased in positive inotropic effect (force of contraction 48.8±1.53 mm) as compared to control group (force of contraction 17.5±0.76 mm) on Langendorff”s study (in vitro study). In doxorubicin-induced congestive heart failure both MELU and OLU showed significant decreased QT (Note: In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle. There is no full form for this medical word) interval. The histopathologic study indicated the least damage to the architecture of myocardial membrane. MELU and OLU increased urine output (5.66±0.16 ml and 6.58±0.15 ml respectively) significantly in Lipschitz model as compared to disease control group (4.58±0.15 ml).Conclusion: Present research work emphasizes that the seeds of Linum usitatissimum is beneficial in the management of congestive heart failure because of having positive inotropic effect, diuretic activity and control of rhythmicity of heart.

Highlights

Heart failure is a common chronic disease that leads to disability and death
In isolated rat heart preparation on Langendorff’s assembly, methanolic extract of seeds of Linum usitatissimum (MELU) showed significant increase in force of contraction when compared to normal response
This indicates that Methanolic extract of seeds of Linumusitatissimum (MELU) possesses positive inotropic effect which can reduce the preload in the heart

Summary

Introduction

Heart failure is a common chronic disease that leads to disability and death. It is the only major cardiovascular disease that has increasing incidence and prevalence [1 2].Treatment strategies have been focused mainly on the use of diuretics and cardiac glycosides. Heart failure is a common chronic disease that leads to disability and death It is the only major cardiovascular disease that has increasing incidence and prevalence [1 2]. Plants have been utilized as medical treatments since the beginning of civilization, in 20th century the herbal medicine has been losing ground to new synthetic medicines [4]. This fact occurs, at least in part, by failure in scientific data about the biological effects of the plants. Consumption of the oil or seed has been reported to have beneficial effects on cardiovascular health and in the treatment of certain cancers and inflammatory diseases [10]. Flaxseed is used in animal feed to increase levels of α-linolenic acid in meat or eggs [12]

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