Abstract
ABSTRACT: The bacterial bioluminescence assay was used to determine the acute toxicity level of beauvericin, which was found to be moderate with an EC50 of 94 ± 9 μg/ml. The Ames test was used to evaluate mutagenicity of this mycotoxin. Assays were carried out on 5 Salmonella typhimurium standard tester strains. The spot test was performed on a single beauvericin concentration of 2 μg/plate. The plate incorporation test was done over a range of concentrations (0.2 to 500 μg/plate), both with and without S9. A negative control and 3 positive controls, 2‐aminofluorene, sodium azide, and dexon, were included in the assays. Beauvericin was nonmutagenic to any of the standard tester strains used, either with or without metabolic activation.
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