Abstract
Echogenic liposomes (ELIP) are vesicles with a phospholipid bilayer shell that can serve as ultrasound contrast agents (UCA) for diagnostic purposes and for targeted drug delivery. The efficacy of ELIP as an UCA depends upon its stability in an acoustic field, whereas the use of ELIP for drug delivery will require releasing the encapsulated drug rapidly at the desired treatment site. The objective of this study was to evaluate the rate of destruction of ELIP as a function of pressure and pulse repetition frequency (PRF). Assuming ELIP destruction is directly related to its echogenicity, transducers with center frequencies of 3.5, 7.5, and 10 MHz were used to acquire pulse-echo data from ELIP suspensions ([lipid]=0.2 mg/ml). The rate of ELIP destruction was defined by fitting an exponential decay function Ae−kt to the backscattered intensity data. The relationship between ELIP destruction and acoustic pressure and PRF was determined by comparing the decay time constant k across samples. Based on this analysis, the rate of ELIP destruction was found to be directly proportional to pressure and PRF for all frequencies tested.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
