Abstract
Spontaneous and pokeweed mitogen (PWM)-induced immunoglobulin-secreting B cells were evaluated in 20 newly diagnosed Graves' disease patients, and 11 of the patients were retested when euthyroid after treatment for 6–10 months with anti-thyroid drugs. Numbers of spontaneous plaque-forming cells (PFC) in patients tested before or after treatment were not significantly different from age- and sex-matched controls, but PWM-induced IgG-, IgA-, and IgM-PFC were significantly reduced in the pretreatment group to approximately one-half the mean control value. After treatment, numbers of PFC were midway between pretreatment and control values. Reduced B-cell activation was not due to circulating in vivo activated suppressor cells nor reduced T helper function. Concanavalin A-induced T suppressor function was normal in all but 2 20 pretreatment and 1 11 post-treatment patients.
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