Abstract

Objective: The value of head-up tilt test (HUTT) for differential diagnosis of epilepsy and the autonomic nervous system functions in
 epileptic children using heart rate variability (HRV) are studied.
 Patients and Methods: The study group consisted of 16 children with idiopatic/criptogenic epilepsy and 12 controls. Heart rate, PR
 interval, corrected QT (QTc) interval, QT and QTc dispersion were calculated using 12-lead electrocardiogram (ECG), HRV analysis
 was performed using the Holter recordings obtained both during HUTT and throughout the day. Time domain parameters, standard
 deviation of all RR intervals (SDNN), the standard deviation of mean NN intervals in five-minutes recording (SDANN), mean standard
 deviation of NN intervals in five-minutes recordings (SDNNi), root mean square of successive differences (RMSSD), count divided
 by the total number of all NN intervals (pNN50) and frequency domain parameters low frequency (LF), high frequency (HF), lowfrequency/
 high-frequency ratio (LF/HF) were calculated in both and compared between the two groups.
 Results: Head-up tilt test was positive in 4 epileptic children (25%), none of controls were positive. The heart rate of the patients were
 higher than the controls (p=0.015). LF/HF ratio in 24-hour Holter recordings, were significantly lower (1.13±0.6, 1.83±0.7 respectively,
 p=0.002); the SDANN during HUTT (28.7±20.2, 18.2 ± 19.9 respectively, p=0.024) were significantly higher in the patients than the
 controls.
 Conclusion: Head-up tilt test positivity is frequent in epileptic children, and cannot be used in differential diagnosis. HRV calculated
 both from 24 hour Holter recordings and Holter recordings under orthostatic stress were impaired in favour of parasympathetic
 system in epileptic children.

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