Abstract
Introduction: End-stage renal disease (ESRD) is one of the health problems in today’s world. Neuropsychological problems are more common in hemodialysis (HD) patients than in healthy individuals. Objectives: The aim of this study was to investigate the effect of long-term HD on memory function of these patients. Patients and Methods: Our study, included 80 HD patients of whom 39 were under 6 months of HD and 41 patients as another group which had a history of HD more than 6 months. Results: The population had a mean age of 51.60 years old (27.5% female). The scores of patients who have been hemodialyzed for a long-time (median time of HD was up to 4 years) had lower score in forward digit (FD), backward digit score test (BD), letter digit modality task (LDMT), letter symbol digit modality task (LSDMT) (5.49; 3.61; 21.12; 17.66) than the HD patients who underwent HD for a shorter term, with the median time of 3 to 5 months (7.38; 4.79; 39.77; 43.38) (P<0.001). Conclusion: The present study demonstrated that end-stage HD patients who were under HD for a long time had significantly lower scores in the memory and attention tests. However, additional researches are needed in this area.
Highlights
End-stage renal disease (ESRD) is one of the health problems in today’s world
This study aimed to investigate the risk of decreasing cognitive function including attention and memory in relation to the duration of dialysis in HD patients
We relied on neuropsychological assessment alone to define memory and attention status
Summary
End-stage renal disease (ESRD) is one of the health problems in today’s world. Neuropsychological problems are more common in hemodialysis (HD) patients than in healthy individuals. Objectives: The aim of this study was to investigate the effect of long-term HD on memory function of these patients. Conclusion: The present study demonstrated that end-stage HD patients who were under HD for a long time had significantly lower scores in the memory and attention tests. One of the neuropsychological problems is cognitive impairment. Studies show that patients undergoing dialysis for longtime have persistent cognitive impairment [4,5]. Several studies have shown that HD patients have significant impairment on cognitive functions [6,7,8]. The impairment in memory and attention in patients with kidney disease may be related to disturbed brain function secondary to uremic toxins, and psychological distress [11,12,13]
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