Evaluation of association of Magnesium levels with Hand Grip Strength in geriatric patients with hip fracture

Abstract

Abstract Introduction/Objective Magnesium is a macronutrient that plays a key role in several cellular processes.It is an essential mineral for bone metabolism. Not much is known about the association of magnesium and the risk of hip fractures in the Asian population. In this case control study, we evaluate the relationship between serum magnesium level and the risk of incident hip fracture. The purpose of this study was to investigate the association between magnesium and hand grip strength in hip fracture risk in the geriatric population residing in North India. Methods/Case Report Seventy-five patients with hip fracture, Group I and a similar number of controls, Group II were enrolled in the study. Samples were analyzed for serum levels of magnesium, 25 hydroxy Vitamin D, alkaline phosphatase, calcium, and phosphate by immunoassay. Hand grip strength of study subjects was measured using dynamometer. Correlation between magnesium levels and hand grip strength was analyzed in study population. Results (if a Case Study enter NA) Among the 75 subjects, 36 were men and 39 were women. The mean age of hip fracture cases was 63.7 ± 8.4 years which was comparable in men and women. Hypomagnesemia was observed in the hip fracture group (1.43 ± 2.36 mg/dl) whereas magnesium level in the control group was normal (2.35 ± 3.86 mg/dl) (p<0.05). 25 hydroxy Vitamin D levels were significantly lower in cases (9.63 ± 4.53 ng/ml) as compared to controls (24.38 ± 5.27 ng/ml). The mean hand grip strength among hip fracture group (18.31 ± 4.69 kg) was significantly lower compared to that of the control group (31.54 ± 6.12 kg). There was a significant positive correlation between magnesium levels and hand grip strength (r=0.74, p<0.05) in hip fracture population. Conclusion Hand grip strength as measured by hand held dynamometer was significantly lower in geriatric hip fracture patients, and there is a significant positive correlation between Magnesium and hand grip strength.