Evaluation of apelin level in women with polycystic ovary syndrome at Al-Najaf Province

Abstract

Hyperinsulinaemia is one of the most common clinical manifestations in women with PCOS. Here, hyperinsulinaemia may increase IGF- 1 expression and aggravate the effect of IGF1 by reducing the synthesis of IGF binding protein 1. IGF1 increases the expression of APLNR, and further promotes oestrogen synthesis and secretion via binding of APLN/APLNR. Patients with PCOS have high ovarian IGF1 levels. Therefore, IGF-1 and APLN may exhibit a compensatory increase in PCOS. Recently study found a high APLN/APLNR level in blood and ovary in PCOS (Liu et al., 2020). One of the first effects of APLN observed was its ability to lower glucose levels in both in fasting conditions and during a glucose tolerance test. Increased glucose uptake in target tissues such as skeletal muscle and adipose tissue was responsible for the decreased glycaemia (Yue et al., 2010).