Abstract
Background: Mimosa pudica belongs to the family of Mimosoideae. Traditional Chinese medicinal practitioners have long revered the bark, leaves and flowers of Mimosa for its potent health benefits. Limited modern scientific research has been conducted on the qualities of this plant. As part of our ongoing research of traditional medicinal plant, this study evaluated the anxiolytic and antibacterial activity of methanol extract of Mimosa pudica (MEMP) leaves. Method: The effect of MEMP on central nervous system (CNS) for anxiolytic activity was determined by mice light-dark box test, Elevated plus maze test and Hole board test. Disc diffusion assay was used to determine the antibacterial activity of MEMP. Result: Preliminary phytochemical screening revealed the presence of reducing sugar, tannin, glycoside, alkaloids and flavonoids. The present study demonstrated that MEMP showed significant anxiolytic (p<0.05) effect at the doses of 200 and 400 mg/kg body weight in Light-dark box test, Elevated plus maze test. The movement of mice after administration of MEMP at doses of 200 and 400 mg/kg body weight decreased significantly in hole-board test, which indicated the high possibility of having anxiolytic activity. The MEMP showed dose-dependent antibacterial activity against the experimental bacterial strains namely Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae, Escherichia coli, and Shigella flexineri. Conclusion: The present study indicates that the MEMP extract possesses anxiolytic and antibacterial activity in a dose-dependent manner. Hence, the present work rationalizes the traditional uses of this plant. So, the plant may be further subjected to chemical investigation to isolate and purify the bioactive compound(s) responsible for its pharmacological activity.
Highlights
The American Psychological Association (APA) defines anxiety as "an emotion characterized by feelings of tension, worried thoughts and physical changes like increased blood pressure." According to the World Health Organization (WHO), 1 in 13 globally suffers from anxiety
As a part of our ongoing study of local medicinal plants of Bangladesh [4,5,6,7,8,9,10], here we evaluated the anxiolytic and antibacterial activity of methanol extract of Mimosa pudica leaves and examined its effectiveness whether it is effective against certain microbes and if it has antianxiety action
Preliminary phytochemical screening of methanol extract of Mimosa pudica (MEMP) showed the presence of reducing sugar, tannins, glycoside, alkaloids and flavonoids (Table 1)
Summary
The American Psychological Association (APA) defines anxiety as "an emotion characterized by feelings of tension, worried thoughts and physical changes like increased blood pressure." According to the World Health Organization (WHO), 1 in 13 globally suffers from anxiety. Bacterial diseases are very common and contagious that can result in many serious or life-threatening complications, such as blood poisoning (bacteremia), kidney failure, and toxic shock syndrome Both primary and secondary phytoconstituents are ubiquitously present in the roots, leaves, shoots, flowers, vegetables and fruits of the medicinal plants that naturally exhibit defense mechanism, pharmacological activities i.e., anti-inflammatory, anticancer, anti-malarial, inhibition of cholesterol synthesis, anti-viral, anti-bacterial and ant-diabetic activities [1]. Mimosa pudica is a sleepy sensitive herb that is found to be useful in alleviating the symptoms of hemorrhoids and acts as a natural astringent, displays antiseptic properties, and is said to impart a cooling effect It encourages new hair cell growth, which may contribute in arresting hair loss.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
